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Peptide-Decorated Dendrimers and Their Bioapplications.
- Source :
-
Angewandte Chemie International Edition . Apr2016, Vol. 55 Issue 17, p5124-5134. 11p. - Publication Year :
- 2016
-
Abstract
- Peptide-decorated dendrimers (PDDs) are a class of spherical, regular, branched polymers that are modified by peptides covalently attached to their surface. PDDs have been used as protein mimetics, novel biomaterials, and in a wide range of biomedical applications. Since their design and development in the late eighties, poly- l-lysine has been a preferred core structure for PDDs. However, numerous recent innovations in polymer synthesis and ligation chemistry have re-energized the field and led to the emergence of well-defined peptide dendrimers with more diverse core structures and functions. This Minireview highlights the development of PDDs driven by significantly improved ligation chemistry incorporating structurally well-defined peptides and the emerging use of PDDs in imaging and drug development. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDES
*DENDRIMERS
*POLYMERS
*BIOMATERIALS
*CHEMICAL synthesis
*LIGATION reactions
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 55
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 114490386
- Full Text :
- https://doi.org/10.1002/anie.201508428