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The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson's disease subjects.
- Source :
-
Canadian Journal of Physiology & Pharmacology . 2016, Vol. 94 Issue 4, p455-461. 7p. 1 Diagram, 1 Chart, 2 Graphs. - Publication Year :
- 2016
-
Abstract
- Increasing evidence suggests that motor rehabilitation may delay Parkinson's disease (PD) progression. Moreover, parallel treatments in animals up-regulate brain-derived neurotrophic factor (BDNF). Thus, we investigated the effect of a motor rehabilitation protocol on PD symptoms and BDNF serum levels. Motor rehabilitation training consisted of a cycle of 20 days/month of physiotherapy divided in 3 daily sessions. Clinical data were collected at the beginning, at the end, and at 90 days follow-up. BDNF serum levels were detected by ELISA at 0, 7, 14, 21, 30, and 90 days. The follow-up period had a duration of 60 days (T30-T90). The results showed that at the end of the treatment (day 30), an improvement in extrapyramidal signs (UPDRS III; UPDRS III - Gait and Balance items), motor (6 Minute Walking Test), and daily living activities (UPDRS II; PDQ-39) was observed. BDNF levels were increased at day 7 as compared with baseline. After that, no changes in BDNF were observed during the treatment and in the successive follow-up. This study demonstrates that motor rehabilitation training is able to ameliorate PD symptoms and to increase temporarily BDNF serum levels. The latter effect may potentially contribute to the therapeutic action. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00084212
- Volume :
- 94
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Canadian Journal of Physiology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 114308489
- Full Text :
- https://doi.org/10.1139/cjpp-2015-0322