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MALAT-1, a novel noncoding RNA, and thymosin ß4 predict metastasis and survival in early-stage non-small cell lung cancer.
- Source :
-
Oncogene . 9/11/2003, Vol. 22 Issue 39, p6087-6097. 11p. 3 Diagrams, 1 Chart, 5 Graphs. - Publication Year :
- 2003
-
Abstract
- Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a substantial fraction of patients ultimately dies due to distant metastasis. In this study, we used subtractive hybridization to identify gene expression differences in stage I NSCLC tumors that either did or did not metastasize in the course of disease. Individual clones (n=225) were sequenced and quantitative RT-PCR verified overexpression in metastasizing samples. Several of the identified genes (eIF4A1, thymosin ß4 and a novel transcript named MALAT-1) were demonstrated to be significantly associated with metastasis in NSCLC patients (n=70). The genes’ association with metastasis was stage- and histology specific. The Kaplan-Meier analyses identified MALAT-1 and thymosin ß4 as prognostic parameters for patient survival in stage I NSCLC. The novel MALAT-1 transcript is a noncoding RNA of more than 8000?nt expressed from chromosome 11q13. It is highly expressed in lung, pancreas and other healthy organs as well as in NSCLC. MALAT-1 expressed sequences are conserved across several species indicating its potentially important function. Taken together, these data contribute to the identification of early-stage NSCLC patients that are at high risk to develop metastasis. The identification of MALAT-1 emphasizes the potential role of noncoding RNAs in human cancer.Oncogene (2003) 22, 6087-6097. doi:10.1038/sj.onc.1206928 [ABSTRACT FROM AUTHOR]
- Subjects :
- *LUNG cancer
*SURGERY
*METASTASIS
*GENE expression
*CHROMOSOMES
*CANCER
Subjects
Details
- Language :
- English
- ISSN :
- 09509232
- Volume :
- 22
- Issue :
- 39
- Database :
- Academic Search Index
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 11426682
- Full Text :
- https://doi.org/10.1038/sj.onc.1206928