One-pot Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1 H )-ones from Aldehydes, Ketones, and Urea under Solvent-free Conditions.

Various 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones were synthesized efficiently by a one-pot three-component condensation of aromatic aldehydes, aromatic ketones, and urea using SnCl2·2H2O as a catalyst under solvent-free conditions. All products were identified by IR, NMR, MS, and elemental analysis. The novel method offers several advantages such as excellent yields (81–95%), short reaction time (5–16 min), broader substrate scope, and environmentally friendly conditions. [ABSTRACT FROM AUTHOR]