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Synthesis of panaxytriol and its stereoisomers as potential antitumor drugs.

Authors :
Mao, Jianyou
Zhong, Jiangchun
Wang, Bo
Jin, Jing
Li, Shuoning
Gao, Zidong
Yang, Hanze
Bian, Qinghua
Source :
Tetrahedron: Asymmetry. May2016, Vol. 27 Issue 7/8, p330-337. 8p.
Publication Year :
2016

Abstract

An efficient synthesis of panaxytriol and its seven stereoisomers was achieved, and four unnatural diastereomers of 2a were prepared. The key steps involved the opening of vicinal hydroxy epoxides, the stereospecific opening of the epoxides with perchloric acid, and the Cadiot–Chodkiewicz cross-coupling of chiral terminal alkynes with bromoalkynes. Preliminary antitumor activity investigations indicated that some synthetic panaxytriols exhibited promising cytotoxic activity against three human cancer cell lines. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09574166
Volume :
27
Issue :
7/8
Database :
Academic Search Index
Journal :
Tetrahedron: Asymmetry
Publication Type :
Academic Journal
Accession number :
114173696
Full Text :
https://doi.org/10.1016/j.tetasy.2016.03.005