Back to Search
Start Over
Successful capecitabine rechallenge following 5-fluorouracil-induced Takotsubo syndrome.
- Source :
-
Oxford Medical Case Reports . Mar2016, Vol. 2016 Issue 3, p47-50. 4p. - Publication Year :
- 2016
-
Abstract
- Cardiac toxicity is a widely reported complication of fluoropyrimidine chemotherapies (5-fluorouracil and capecitabine); however, Takotsubo syndrome (TS) is less widely reported. There is little data available describing the viability of fluoropyrimidine rechallenge after fluoropyrimidine-induced TS. We report the case of Ms X, a 41-year-old woman with metastatic oesophageal cancer, who developed acute onset left ventricular dysfunction, with a measured left ventricular ejection fraction of 15% on cycle 1 day 3 of FOLFOX chemotherapy, after disconnection of the fluorouracil infusion pump. Her symptoms resolved over 2 days, and an echocardiogram returned to normal within 2 weeks. 5-Fluorouracil was discontinued, and replaced with capecitabine, without recurrence of symptoms. The remainder of her treatment was uneventful. This is the second case to describe successful capecitabine retreatment following 5-fluorouracil-induced TS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FLUOROURACIL
*ANTINEOPLASTIC agents
*TAKOTSUBO cardiomyopathy
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 20538855
- Volume :
- 2016
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Oxford Medical Case Reports
- Publication Type :
- Academic Journal
- Accession number :
- 114047115
- Full Text :
- https://doi.org/10.1093/omcr/omv072