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Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation.
- Source :
-
Vaccine . Apr2016, Vol. 34 Issue 18, p2055-2061. 7p. - Publication Year :
- 2016
-
Abstract
- Although adjuvants are a “must-have” component of successful vaccines, there are very few adjuvants licensed for use in humans, there is therefore an urgent need to develop new and safer adjuvants. Synthetic hemozoin (sHZ), a chemical analog of hemozoin which is produced by the malaria parasite, exhibits a potent adjuvant effect which enhances antigen-specific immune responses to vaccines. The potency of sHZ adjuvanticity is not limited to malaria specific vaccines, it has also been demonstrated to be effective in influenza and dog allergy models. While the synthesis of uniformly sized sHZ with consistent characteristics has proven difficult, we have recently successfully optimized the manufacture of sHZ product with an optimal adjuvant effect. Here, we summarize recent developments on the adjuvant properties of optimized sHZ adjuvant, including its good laboratory practice (GLP) non-clinical safety profile in animals. These studies ensure the safety of optimized sHZ product to be readily used as vaccine adjuvant beforehand in veterinary medicine. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOLOGICAL adjuvants
*VACCINES
*MALARIA
*IMMUNE response
*VETERINARY medicine
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 34
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 114023007
- Full Text :
- https://doi.org/10.1016/j.vaccine.2016.02.064