Palladium catalyzed Mizoroki–Heck reaction of pyrimidin-2-yl tosylates with aromatic and aliphatic olefins.

Pyrimidin-2-yl tosylates which are successfully applied as the electrophiles instead of halides coupled with olefins via Pd(PPh 3 ) 2 Cl 2 catalyzed Mizoroki–Heck reaction conditions to give the corresponding C2-alkenyl pyrimidine derivatives with high β -regioselectivity. This protocol proves to be tolerant of various pyrimidin-2-yl tosylates as well as various olefins including styrene derivatives, aliphatic olefins (vinyl cyanide, methyl acrylate, ethyl acrylate, n -butyl acrylate, butyl vinyl ether, 1-hexene and 1-octene). [ABSTRACT FROM AUTHOR]