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The Emerging Function and Mechanism of ceRNAs in Cancer.
- Source :
-
Trends in Genetics . Apr2016, Vol. 32 Issue 4, p211-224. 14p. - Publication Year :
- 2016
-
Abstract
- Complex diseases, such as cancer, are often associated with aberrant gene expression at both the transcriptional and post-transcriptional level. Over the past several years, competing endogenous RNAs (ceRNAs) have emerged as an important class of post-transcriptional regulators that alter gene expression through a miRNA-mediated mechanism. Recent studies in both solid tumors and hematopoietic malignancies showed that ceRNAs have significant roles in cancer pathogenesis by altering the expression of key tumorigenic or tumor-suppressive genes. Characterizing the identity, function, and mechanism of the ceRNAs will not only further our fundamental understanding of RNA-mediated cancer pathogenesis, but may also shed light on the development of new RNA-based therapeutic strategies for treating cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RNA
*GENE expression
*NUCLEIC acids
*CANCER
*TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 01689525
- Volume :
- 32
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Trends in Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 113898633
- Full Text :
- https://doi.org/10.1016/j.tig.2016.02.001