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Global Analysis of Predicted G Protein2Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa.
- Source :
-
G3: Genes | Genomes | Genetics . 12/1/2015, Vol. 5 Issue 12, p2729-2743. 15p. - Publication Year :
- 2015
-
Abstract
- Gprotein-coupled receptors (GPCRs) regulate facets of growth, development, and environmental sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class in these organisms is the Pth11-related, with members similar to a protein required for disease in the plant pathogen Magnaporthe oryzae. However, the Pth11-related class has not been functionally studied in any filamentous fungal species. Here, we analyze phenotypes in available mutants for 36 GPCR genes, including 20 Pth11-related, in the model filamentous fungus Neurospora crassa. We also investigate patterns of gene expression for all 43 predicted GPCR genes in available datasets. A total of 17 mutants (47%) possessed at least one growth or developmental phenotype. We identified 18 mutants (56%) with chemical sensitivity or nutritional phenotypes (11 uniquely), bringing the total number of mutants with at least one defect to 28 (78%), including 15 mutants (75%) in the Pth11-related class. Gene expression trends for GPCR genes correlated with the phenotypes observed for many mutants and also suggested overlapping functions for several groups of co-transcribed genes. Several members of the Pth11-related class have phenotypes and/or are differentially expressed on cellulose, suggesting a possible role for this gene family in plant cell wall sensing or utilization. [ABSTRACT FROM AUTHOR]
- Subjects :
- *G protein coupled receptors
*NEUROSPORA crassa
*FILAMENTOUS fungi
Subjects
Details
- Language :
- English
- ISSN :
- 21601836
- Volume :
- 5
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- G3: Genes | Genomes | Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 113847222
- Full Text :
- https://doi.org/10.1534/g3.115.020974