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Is in vivo amyloid distribution asymmetric in primary progressive aphasia?
- Source :
-
Annals of Neurology . Mar2016, Vol. 79 Issue 3, p496-501. 6p. - Publication Year :
- 2016
-
Abstract
- We aimed to determine whether (18) F-florbetapir amyloid positron emission tomography imaging shows a clinically concordant, left-hemisphere-dominant pattern of deposition in primary progressive aphasia (PPA). Elevated cortical amyloid (Aβ(+) ) was found in 19 of 32 PPA patients. Hemispheric laterality of amyloid burden was compared between Aβ(+) PPA and an Aβ(+) amnestic dementia groups (n = 22). The parietal region showed significantly greater left lateralized amyloid uptake in the PPA group than the amnestic group (p < 0.007), consistent with the left lateralized pattern of neurodegeneration in PPA. These results suggest that the cortical distribution of amyloid may have a greater clinical concordance than previously reported. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03645134
- Volume :
- 79
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Annals of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 113704280
- Full Text :
- https://doi.org/10.1002/ana.24566