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Synchronous glioblastoma and medulloblastoma in a child with mismatch repair mutation.
- Source :
-
Child's Nervous System . Mar2016, Vol. 32 Issue 3, p553-557. 5p. - Publication Year :
- 2016
-
Abstract
- Synchronous primary malignant brain tumors are rare. We present a 5-year-old boy with synchronous glioblastoma and medulloblastoma. Both tumor samples had positive p53 stain and loss of PMS2 and MLH1 stains. The child had multiple café au lait spots and a significant family history of cancer. After subtotal resection of both tumors, he received craniospinal radiation with concomitant temozolomide followed by chemotherapy, alternating cycles of cisplatin/lomustine/vincristine with temozolomide. Then, he started maintenance treatment with cis-retinoic acid (100 mg/m/day for 21 days). He remained asymptomatic for 34 months despite a follow-up brain MRI consistent with glioblastoma relapse 9 months before his death. Cis-retinoic acid may have contributed to prolong survival in this child with a probable biallelic mismatch repair syndrome. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DNA repair
*TRETINOIN
Subjects
Details
- Language :
- English
- ISSN :
- 02567040
- Volume :
- 32
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Child's Nervous System
- Publication Type :
- Academic Journal
- Accession number :
- 113445109
- Full Text :
- https://doi.org/10.1007/s00381-015-2883-3