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Daidzein-loaded nanostructured lipid carriers-PLGA nanofibers for transdermal delivery.
- Source :
-
International Journal of Pharmaceutics . Mar2016, Vol. 501 Issue 1/2, p245-252. 8p. - Publication Year :
- 2016
-
Abstract
- Daidzein is one of the most effective candidates for treating cardiovascular and cerebrovascular disease. However, considering its poor oral absorption and limited bioavailability, daidzein-loaded nanostructured lipid carriers-PLGA nanofibers were designed to handle the drawbacks. Daidzein-NLCs were successfully prepared by an emulsification and low-temperature solidification method. The physicochemical characteristics of NLCs were evaluated afterwards. Based on the preparation of daidzein-loaded NLCs, Daidzein-NLCs-nanofibers were optimized by electrospinning and were observed under Scanning Electron Microscope to capture the appearance. The sustained release profile of daidzein from Daidzein-NLCs-nanofibers in vivo was best fitted to the Kormeyer-Peppas equation. The in vitro skin permeable behavior showed the cumulative amount of daidzein from Daidzein-NLCs-nanofibers reached 21.71 μg cm −2 at 60 h, which was 3.78 times higher than pure daidzein solution. It demonstrated that the Daidzein-NLCs-nanofibers could significantly enhance the transported amount of drug. Confocal Laser Scanning Microscopy resulting images revealed a more effective content accumulation of Daidzein-NLCs-nanofibers than Daidzein-NLCs in epidermis. In vivo study indicated that Daidzein-NLCs-nanofibers had better skin retention than Daidzein-NLCs in the long term. The skin irritation experiment showed a positive result with no obvious stimulus observed. These results suggested that Daidzein-NLCs-nanofibers could be a potential candidate for transdermal delivery. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DAIDZEIN
*NANOCARRIERS
*TRANSDERMAL medication
*POLYLACTIC acid
*NANOFIBERS
*LIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 03785173
- Volume :
- 501
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 113403860
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2016.02.003