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Lewis Acid Catalyzed Synthesis of α-Trifluoromethyl Esters and Lactones by Electrophilic Trifluoromethylation.
- Source :
-
Organic Letters . Dec2015, Vol. 17 Issue 23, p5898-5901. 4p. - Publication Year :
- 2015
-
Abstract
- An electrophilic trifluoromethylation of ketene silyl acetals (KSAs) by hypervalent iodine reagents 1 and 2 has been developed. The reaction proceeds under very mild conditions in the presence of a catalytic amount of trimethylsilyl bis(trifluoromethanesulfonyl)imide (up to 2.5 mol %) as a Lewis acid providing a direct access to a variety of secondary, tertiary, and quaternary a-trifluoromethyl esters and lactones in high yield (up to 98%). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 17
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 113388638
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b03088