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Amino Acid Mixture Enriched With Arginine, Alanine, and Phenylalanine Stimulates Fat Metabolism During Exercise.
- Source :
-
International Journal of Sport Nutrition & Exercise Metabolism . Feb2016, Vol. 26 Issue 1, p46-54. 9p. 1 Diagram, 4 Charts, 2 Graphs. - Publication Year :
- 2016
-
Abstract
- Although there have been many investigations of the beneficial effects of both exercise and amino acids (AAs), little is known about their combined effects on the single-dose ingestion of AAs for lipid metabolism during exercise. We hypothesize that taking a specific combination of AAs implicated in glucagon secretion during exercise may increase fat metabolism. We recently developed a new mixture, d-AA mixture (D-mix), that contains arginine, alanine, and phenylalanine to investigate fat oxidation. In a double-blind, placebo-controlled crossover study, 10 healthy male volunteers were randomized to ingest either D-mix (3 g/dose) or placebo. Subjects in each condition subsequently performed a physical task that included workload trials on a cycle ergometer at 50% of maximal oxygen consumption for 1 hr. After oral intake of D-mix, maximum serum concentrations of glycerol (9.32 ± 6.29 mg/L and 5.22 ± 2.22 mg/L, respectively; p = .028), free fatty acid level (0.77 ± 0.26 mEq/L and 0.63 ± 0.28 mEq/L, respectively; p = .022), and acetoacetic acid levels (37.9 ± 17.7 µmol/L and 30.3 ± 13.9 µmol/L, respectively; p = .040) were significantly higher than in the placebo groups. The area under the curve for glucagon during recovery was numerically higher than placebo (6.61 ± 1.33 µg/L ⋅ min and 6.06 ± 1.23 µg/L ⋅ min, respectively;p = .099). These results suggest thatpreexercise ingestion of D-mix may stimulate fat metabolism. Combined with exercise, the administration of AA mixtures could prove to be a useful nutritional strategy to maximize fat metabolism. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPID metabolism
*OXYGEN analysis
*ACETIC acid
*ALANINE
*ANALYSIS of variance
*ARGININE
*CROSSOVER trials
*CYCLING
*DIETARY supplements
*EXERCISE
*FATTY acids
*GLUCAGON
*GLYCERIN
*HEART beat
*PHENYLALANINE
*PLACEBOS
*PROBABILITY theory
*STATISTICS
*T-test (Statistics)
*DATA analysis
*RANDOMIZED controlled trials
*REPEATED measures design
*OXYGEN consumption
*ERGOMETRY
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 1526484X
- Volume :
- 26
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Sport Nutrition & Exercise Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 113369645
- Full Text :
- https://doi.org/10.1123/ijsnem.2015-0137