Antitumor effect of superparamagnetic iron oxide nanoparticles conjugated with doxorubicin during magnetic nanotherapy of Lewis Lung carcinoma.

Superparamagnetic Iron(II,III) oxide Fe3O4 nanoparticles (NP) in magnetic nanocomplex (MNC2) with antitumor drug doxorubicin (DOXO) induced a greater antitumor and antimetastatic effect compared to the magnetic nanocomplex (MNC1) composed of ferromagnetic nanoparticles with DOXO and conventional DOXO during magnetic nanotherapy of animals with Lewis lung carcinoma. The intratumor temperature did not exceed 39 °C. MNC2 had g-factors of 2.00, 2.30 and 4.00. MNC1 had the g-factor of 2.50. The MNC2 increased the content of Nitric oxide - Iron(II) sulfide protein N complex and NADH-ubiquinone in tumor as compared to MNC1 or conventional DOXO. The results have been analyzed in terms of increased level of reactive oxygen species which could induce death of tumor cells. [ABSTRACT FROM AUTHOR]