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Oral cyclophosphamide in recurrent ovarian cancer.
- Source :
-
Asia Pacific Journal of Clinical Oncology . Mar2016, Vol. 12 Issue 1, pe154-e160. 7p. - Publication Year :
- 2016
-
Abstract
- Aims Cyclophosphamide was widely used as a single agent prior to the advent of platinum-based regimens for epithelial ovarian cancer, and, in combination with platinum, prior to the adoption of platinum and paclitaxel as standard first-line therapy. As cyclophosphamide currently has no defined role in ovarian cancer we aimed to assess its activity in women with recurrent disease. Methods A retrospective review was conducted of patients from three centers in Melbourne, Australia who had received oral cyclophosphamide treatment for recurrent ovarian cancer. The primary end-point was response rate to oral cyclophosphamide (150 mg p.o. day 1-14) based on Gynecologic Cancer InterGroup ( GCIG) CA125 and/or Response Evaluation Criteria in Solid Tumors ( RECIST) criteria. Secondary end-points included overall and progression-free survival and toxicity. Results In all, 26 patients were identified and 23 patients were evaluable for response. The median number of prior chemotherapy regimens was three (range 1-6). The response rate to oral cyclophosphamide was 44% with 10 of the 23 patients achieving a partial response ( PR) based on GCIG ( CA125) criteria. The median number of cycles received was three (range 1-16). Cyclophosphamide showed activity both in patients with platinum-sensitive (seven of 13 PR) and resistant or refractory disease (three of 10 PR). There was no grade 3 or 4 toxicity but two patients ceased cyclophosphamide due to less severe non-hematological toxicity. Conclusion Single agent oral cyclophosphamide is active and well tolerated in recurrent ovarian cancer. Further investigation of oral cyclophosphamide in patients with platinum-sensitive and platinum-resistant disease is warranted. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17437555
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Asia Pacific Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 113306511
- Full Text :
- https://doi.org/10.1111/ajco.12074