Back to Search
Start Over
Platelet to Lymphocyte Ratio as a Prognostic Marker of In-Hospital and Long-Term Major Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction.
- Source :
-
Angiology . Apr2016, Vol. 67 Issue 4, p336-345. 10p. - Publication Year :
- 2016
-
Abstract
- We assessed the prognostic value of the platelet to lymphocyte ratio (PLR) on in-hospital and long-term major adverse cardiovascular events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) in a large prospective study. Patients (n = 1938) admitted with acute STEMI within 12 hours of symptom onset and who underwent pPCI between January 2010 and January 2015 were followed up for 31.6 ± 16.2 months. During the in-hospital and long-term follow-up period, MACE, the prevalence of stent thrombosis, nonfatal myocardial infarction, and mortality were higher in the third PLR tertile group. A PLR in the third tertile had 2.4-fold increased risk of in-hospital MACE and 2.8-fold risk of long-term MACE. The PLR was significantly and positively correlated with peak creatine kinase MB (CK-MB) levels (r = 0.562, P < .001) and Gensini score (r = 0.408, P < .001). Kaplan-Meier analysis of long-term MACE-free survival revealed a higher occurrence of MACE in the third PLR tertile group compared to the other tertiles. In conclusion, the PLR may be a marker of inflammatory and prothrombotic status and predicted in-hospital and long-term MACE in a population with STEMI. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACADEMIC medical centers
*BIOMARKERS
*BLOOD platelets
*CHI-squared test
*CONFIDENCE intervals
*CORONARY disease
*CREATINE kinase
*DOPPLER echocardiography
*FISHER exact test
*INFLAMMATION
*LONGITUDINAL method
*LYMPHOCYTES
*MYOCARDIAL infarction
*MYOCARDIAL revascularization
*PROBABILITY theory
*STATISTICS
*SURGICAL stents
*TRANSLUMINAL angioplasty
*MULTIPLE regression analysis
*PROPORTIONAL hazards models
*DATA analysis software
*DESCRIPTIVE statistics
*HOSPITAL mortality
*KAPLAN-Meier estimator
*ODDS ratio
*KRUSKAL-Wallis Test
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 67
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 113293106
- Full Text :
- https://doi.org/10.1177/0003319715591751