Neurodegenerative disease in 2015: Targeting tauopathies for therapeutic translation.

Tau protein abnormalities are key pathogenic features of Alzheimer disease and other neurodegenerative diseases. In 2015, new studies of the less common tauopathies, including progressive supranuclear palsy, chronic traumatic encephalopathy and frontotemporal lobar degeneration, have identified in vivo biomarkers and mechanisms that initiate tau pathology. [ABSTRACT FROM AUTHOR]