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Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4+ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy.
- Source :
-
Journal of Infectious Diseases . 3/15/2016, Vol. 213 Issue 6, p1008-1012. 5p. - Publication Year :
- 2016
-
Abstract
- Long-term treatment with interferon (IFN) alfa plus ribavirin decreases the proviral human immunodeficiency virus type 1 (HIV) DNA level. However, the short-term impact of IFN alfa on persistent HIV and its effects on immune activation after antiretroviral therapy remain unknown. Our study showed that the cell-associated HIV RNA level and CD4(+) T-cell activation decreased in the IFN group (n = 10). No changes were detected in levels of residual plasma viremia, replication-competent reservoirs, proviral DNA, or 2-long-terminal repeat circles, although APOBEC3G, TRIM5α, BST2, and TRIM22 were upregulated in the IFN group. These data suggest that short-term treatment with IFN alfa combined with RBV decreases HIV expression, in part through inhibition of HIV transcription by TRIM22 and decrease in T-cell activation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERFERON alpha
*HIV
*CD4 antigen
*T cells
*HIV-positive persons
*HEPATITIS C
*ANTIRETROVIRAL agents
*PATIENTS
*THERAPEUTICS
*THERAPEUTIC use of proteins
*HIV infection complications
*ANTIVIRAL agents
*GENES
*HEPATITIS viruses
*IMMUNOLOGY technique
*POLYETHYLENE glycol
*PROTEINS
*RECOMBINANT proteins
*RESEARCH funding
*RIBAVIRIN
*ANTI-HIV agents
*MIXED infections
*DISEASE complications
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 213
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 113211632
- Full Text :
- https://doi.org/10.1093/infdis/jiv521