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Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men.
- Source :
-
Journal of Infectious Diseases . 3/1/2016, Vol. 213 Issue 5, p771-775. 5p. - Publication Year :
- 2016
-
Abstract
- The aging of the human immunodeficiency virus type 1 (HIV-1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤ 35 years or ≥ 50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infection genetics
*HIV infections
*THERAPEUTICS
*CHEMOKINES
*ANTIRETROVIRAL agents
*LIPOPOLYSACCHARIDES
*OLDER HIV-positive persons
*GENE expression in mammals
*T cells
*ANTI-HIV agents
*AGING
*BACTERIAL physiology
*HIV
*IMMUNITY
*IMMUNOLOGY technique
*INFLAMMATION
*INFLAMMATORY mediators
*RESEARCH funding
*GENOTYPES
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 213
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 113197261
- Full Text :
- https://doi.org/10.1093/infdis/jiv501