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Soluble CD14: An Independent Biomarker for the Risk of Mother-to-Child Transmission of HIV in a Setting of Preexposure and Postexposure Antiretroviral Prophylaxis.
- Source :
-
Journal of Infectious Diseases . 3/1/2016, Vol. 213 Issue 5, p762-765. 4p. - Publication Year :
- 2016
-
Abstract
- Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of mother-to-child transmission (MTCT) of HIV, we nested a case-control study (49 pairs of infants and their HIV-infected mothers) within the Six-Week Extended-Dose Nevirapine trial. Median peripartum maternal log2 sCD14 concentration was higher among transmitters (defined as pairs in which maternally transmitted HIV infection occurred by 12 months of age) than nontransmitters (20.29 pg/mL vs 19.41 pg/mL; P = .005). There was an increased odds of MTCT for every log2 increase in maternal sCD14 concentration, after adjustment for maternal HIV load, CD4 count and cART exposure (adjusted odds ratio, 3.51; 95% confidence interval, 1.21-10.21). Maternal monocyte activation may adversely influence the risk of MTCT of HIV. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CD14 antigen
*MATERNAL-fetal exchange
*THERAPEUTIC use of biochemical markers
*HIV infection transmission
*ANTIRETROVIRAL agents
*ANTIBIOTIC prophylaxis
*ANTIGENS
*BREASTFEEDING
*BREAST milk
*HIV
*HIV infections
*PREVENTIVE health services
*RESEARCH funding
*STATISTICAL sampling
*RANDOMIZED controlled trials
*CASE-control method
*VERTICAL transmission (Communicable diseases)
*ANTI-HIV agents
*PHARMACODYNAMICS
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 213
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 113197259
- Full Text :
- https://doi.org/10.1093/infdis/jiv479