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Biodegradation of sulfamethoxazole photo-transformation products in a water/sediment test.

Authors :
Su, Tong
Deng, Huiping
Benskin, Jonathan P.
Radke, Michael
Source :
Chemosphere. Apr2016, Vol. 148, p518-525. 8p.
Publication Year :
2016

Abstract

Occurrence of the antibiotic sulfamethoxazole (SMX) in the aquatic environment is of concern due to its potential to induce antibiotic resistance in pathogenic bacteria. While degradation of SMX can occur by numerous processes, the environmental fate of its transformation products (TPs) remains poorly understood. In the present work, biodegradation of SMX photo-TPs was investigated in a water/sediment system. Photo-TPs were produced by exposing SMX to artificial sunlight for 48 h. The resulting mixture of 8 photo-TPs was characterized using a combination of ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry and tandem mass spectrometry, and then used in biodegradation experiments. Significant differences in transformation among SMX photo-TPs were observed in the water/sediment system, with four photo-TPs displaying evidence of biodegradation (dissipation half-lives [DT 50 ] of 39.7 d for 3-amino-5-methylisoxazole, 12.7 d for 4-nitro-sulfamethxoazole, 7.6 d for an SMX isomer and 2.4 d for [C 10 H 13 N 3 O 4 S]), two displaying primarily abiotic degradation (DT 50 of 31 d for sulfanilic acid and 74.9 d for 5-methylisoxazol-3-yl-sulfamate), and two photo-TPs behaving largely recalcitrantly. Remarkably, TPs previously reported to be photo-stable also were persistent in biodegradation experiments. The most surprising observation was an increase in SMX concentrations when the irradiated solution was incubated, which we attribute to back-transformation of certain photo-TPs by sediment bacteria (85% from 4-nitro-sulfamethoxazole). This process could contribute to exposure to SMX in the aquatic environment that is higher than one would expect based on the fate of SMX alone. The results highlight the importance of considering TPs along with their parent compounds when characterizing environmental risks of emerging contaminants. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00456535
Volume :
148
Database :
Academic Search Index
Journal :
Chemosphere
Publication Type :
Academic Journal
Accession number :
112907724
Full Text :
https://doi.org/10.1016/j.chemosphere.2016.01.049