Tolerogenic Vaccines for Multiple Sclerosis.

The article discusses a study that examined issues in using tolerogenic vaccination for the treatment of multiple sclerosis (MS) patients. Topics include allergen-specific immunotherapy (ASIT), the function of T helper (Th) cells, programmed cell death protein-1 (PD-1) negative receptor and the experimental autoimmune encephalomyelitis (EAE) animal model. Findings indicated the need to include inverse adjuvants through the use of deoxyribonucleic acid (DNA) vaccinations for efficacy.