Genetic screening of the makorin ring finger 3 gene in girls with idiopathic central precocious puberty.

The article discusses a study of the makorin ring finger 3 gene in girls with idiopathic central precocious puberty (CPP) where 105 Taiwanese girls presented with idiopathic CPP from 105 unrelated families were recruited. The findings demonstrated the new idiopathic CPP cases with MKRN3 mutations, uncovered 3 novel missense mutations within MKRN3 and supported the hypothesis that this gene is one critical factor in the control of puberty development.