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Prognostic Significance of Mild Cognitive Impairment Subtypes for Dementia and Mortality: Data from the NEDICES Cohort.
- Source :
-
Journal of Alzheimer's Disease . 2016, Vol. 50 Issue 3, p719-731. 13p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>The predictive value of diverse subtypes of mild cognitive impairment (MCI) for dementia and death is highly variable.<bold>Objective: </bold>To compare the predictive value of several MCI subtypes in progression to dementia and/or mortality in the NEDICES (Neurological Disorders in Central Spain) elderly cohort.<bold>Methods: </bold>Retrospect algorithmic MCI subgroups were established in a non-dementia baseline NEDICES cohort using Spanish adaptations of the original Mini-Mental State Examination (MMSE-37) and Pfeffer's Functional Activities Questionnaire (Pfeffer-11). The presence of MCI was defined according two cognitive criteria: using two cut-offs points on the total MMSE-37 score. Five cognitive domains were used to establish the MCI subtypes. Functional capacity (Pfeffer-11) was preserved or minimally impaired in all MCI participants. The incident dementia diagnoses were established by specialists and the mortality data obtained from Spanish official registries.<bold>Results: </bold>3,411 participants without dementia were assessed in 1994-5. The baseline prevalence of MCI varied according to the MCI definition (4.3%-31.8%). The follow-up was a mean of 3.2 years (1997-8). The dementia incidence varied between 14.9 and 71.8 per 1,000/person-years. The dementia conversion rate was increased in almost all MCI subgroups (p > 0.01), and mortality rate was raised only in four MCI subtypes. The amnestic-multi-domain MCI (aMd-MCI) had the best dementia predictive accuracy (highest positive likelihood ratio and highest clinical utility when negative).<bold>Conclusions: </bold>Those with aMd-MCI were at greatest risk of progression to dementia, as in other surveys and might be explored with increased attention in MCI research and in dementia preventive trials. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MILD cognitive impairment
*DEMENTIA research
*MINI-Mental State Examination
*COGNITIVE testing
*NEUROLOGICAL disorders
*COGNITION disorders diagnosis
*DIAGNOSIS of dementia
*ALGORITHMS
*COGNITION disorders
*LONGITUDINAL method
*NEUROPSYCHOLOGICAL tests
*PROGNOSIS
*PSYCHOLOGICAL tests
*QUESTIONNAIRES
*PREDICTIVE tests
*PROPORTIONAL hazards models
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 50
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 112844707
- Full Text :
- https://doi.org/10.3233/JAD-150625