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A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.
- Source :
-
European Journal of Nutrition . Feb2016, Vol. 55 Issue 1, p383-392. 10p. - Publication Year :
- 2016
-
Abstract
- Purpose: To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. Methods: In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. Serum 25(OH)D, parathyroid hormone, calcium, biomarkers of liver and renal function were measured at multiple time points. Results: The mean (SD) serum 25(OH)D at baseline was 31.6 (8.7) nmol/L, and the dose-response relationship was curvilinear with a plateau around 6 weeks for all doses. At week 16, 25(OH)D was increased by 6.0 (6.5), 21.7 (15.8), 26.3 (12.6), 32.0 (12.8) and 36.3 (26.0) nmol/L for 0, 400, 800, 1200 and 2000 IU/d (all P ≤ 0.002), corresponding to approximately 19, 53, 67, 77 and 80 % of reversion of vitamin D deficiency, respectively. Daily intake of 800 IU vitamin D3 reached a targeted 25(OH)D ≥ 30 nmol/L in at least 97.5 % of Chinese, but not a targeted 25(OH)D ≥ 50 nmol/L even with 2000 IU/d. Change of 25(OH)D was inversely associated with change of PTH concentration ( r = −0.39, P < 0.001) after controlling for age and sex. No between-group differences were observed in terms of the change in serum calcium, alanine transaminase, aspartate aminotransferase, gamma-glutamyltransferase and creatinine ( P ≥ 0.22). Conclusions: Supplementation with 400, 800, 1200 or 2000 IU/d vitamin D could improve the vitamin D deficiency with various degrees. Whether 2000 IU/d vitamin D3 would generate a better result without side effect requires more studies with larger samples in future. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D deficiency
*ANALYSIS of covariance
*ANALYSIS of variance
*CALCIUM
*CHINESE people
*DIETARY supplements
*DOSE-effect relationship in pharmacology
*FISHER exact test
*INTERVIEWING
*KIDNEY function tests
*LIVER function tests
*LONGITUDINAL method
*NUTRITIONAL assessment
*ORAL drug administration
*PARATHYROID hormone
*PROBABILITY theory
*QUESTIONNAIRES
*RESEARCH funding
*STATISTICAL sampling
*STATISTICAL hypothesis testing
*STATISTICS
*VITAMIN D
*DATA analysis
*MULTIPLE regression analysis
*CHOLECALCIFEROL
*BODY mass index
*LIFESTYLES
*RANDOMIZED controlled trials
*BLIND experiment
*FOOD diaries
*PHYSICAL activity
*DATA analysis software
*DESCRIPTIVE statistics
*KRUSKAL-Wallis Test
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 55
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 112692615
- Full Text :
- https://doi.org/10.1007/s00394-015-0859-4