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Toxocara canis: Larvicidal activity of fatty acid amides.

Authors :
Mata-Santos, Taís
D’Oca, Caroline da Ros Montes
Mata-Santos, Hílton Antônio
Fenalti, Juliana
Pinto, Nitza
Coelho, Tatiane
Berne, Maria Elisabeth
da Silva, Pedro Eduardo Almeida
D’Oca, Marcelo Gonçalves Montes
Scaini, Carlos James
Source :
Bioorganic & Medicinal Chemistry Letters. Feb2016, Vol. 26 Issue 3, p739-741. 3p.
Publication Year :
2016

Abstract

Considering the therapeutic potential of fatty acid amides, the present study aimed to evaluate their in vitro activity against Toxocara canis larvae and their cytotoxicity for the first time. Linoleylpyrrolidilamide was the most potent, with a minimal larvicidal concentration (MLC) of 0.05 mg/mL and 27% cytotoxicity against murine peritoneal macrophages C57BL/6 mice, as assessed by the MTT assay. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0960894X
Volume :
26
Issue :
3
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
112676705
Full Text :
https://doi.org/10.1016/j.bmcl.2016.01.002