老年慢性阻塞性肺疾病患者踝-臂脉搏波传导速度、踝臂指数的相关性.

Objective To study the level of brachial-ankle pulse wave velocity （ba-PWV） and Ankle Brachial Index （ABI） in elderly Chronic Obstructive Pulmonary Disease （COPD） patients,and to investigate the relations of ba-PWV, ABI and pulmonary function, inflammatory factor in elderly COPD patients. Methods According to the results of the pulmonary function test, 109 cases were divided into three groups：mild- to- moderate COPD group of 42 cases, severe and very severe COPD group of 31 cases, control group of 36 cases. Comparing the level of ba-PWV、 ABI、 inflammatory factor、 pulmonary function in three groups. Results The average ba-PWV of mild- to- moderate COPD group and severe and very severe COPD group were higher than control group （P〈0.01）, the average ba-PWV of severe and very severe COPD group was higher than mild- to- moderate COPD group （P〈0.01）. The compare of the average ABI among three groups had no statistical significance （P〉0.05）. The FEV1：FVC ratio and the percent predicted FEV1 were negatively correlated with the average ba-PWV （P〈0.01）. The hs-CRP、 IL- 6、 TNF-a were positively correlated with the average ba-PWV in all research object （P〈0.01）. Conclusions The elderly COPD patients arterial stiffness is worse than control group with no COPD.The level of ba-PWV is positively correlated with the severity of airway obstruction and the levels of inflammatory factors The elevated levels of inflammatory factors may be one of the factors influencing arterial stiffness in COPD patients. [ABSTRACT FROM AUTHOR]