Back to Search
Start Over
Motor and non-motor outcomes of continuous apomorphine infusion in 125 Parkinson's disease patients.
- Source :
-
Parkinsonism & Related Disorders . Feb2016, Vol. 23, p17-22. 6p. - Publication Year :
- 2016
-
Abstract
- <bold>Introduction: </bold>Continuous apomorphine infusion (CAI) is an effective treatment in fluctuating Parkinson's disease (PD). However, long-term efficacy and safety data of CAI are scarce.<bold>Methods: </bold>We retrospectively reviewed long-term outcomes of CAI on motor and non-motor symptoms in a Dutch cohort of 125 PD patients.<bold>Results: </bold>Our cohort (age: 65.8 ± 9.8 years, disease duration: 11.9 ± 5.7 years) had a mean daily dose of apomorphine of 66 ± 30 mg, thereby reducing the levodopa-equivalent daily dose (LEDD) by 20%. The mean duration of treatment with apomorphine was 32.3 ± 31.9 months, ranging up to 139 months. Three-quarters of patients discontinued within the first four years. The main reason for discontinuation was a decreasing therapeutic effect. Patients who stopped apomorphine within four years had a lower LEDD reduction at hospital discharge and at last follow-up compared to patients who continued for a longer period. CAI showed good effects on motor fluctuations and dyskinesia, with better outcomes in patients with more pronounced LEDD reduction. CAI could be safely applied in patients with pre-existing visual hallucinations (30%).<bold>Conclusion: </bold>CAI showed beneficial effects on motor and several non-motor symptoms, whereas the magnitude of LEDD reduction seems to be a positive predictive factor on the duration of CAI. [ABSTRACT FROM AUTHOR]
- Subjects :
- *APOMORPHINE
*PARKINSON'S disease treatment
*HEALTH outcome assessment
*INFUSION therapy
*PARKINSON'S disease patients
*HALLUCINATIONS
*DRUG therapy for Parkinson's disease
*ANTIPARKINSONIAN agents
*PARKINSON'S disease
*TREATMENT effectiveness
*RETROSPECTIVE studies
*SUBCUTANEOUS infusions
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 13538020
- Volume :
- 23
- Database :
- Academic Search Index
- Journal :
- Parkinsonism & Related Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 112630220
- Full Text :
- https://doi.org/10.1016/j.parkreldis.2015.11.013