Global hypomethylation in myeloma is associated with poor prognosis.

The article focuses on study related to multiple myeloma and role of global hypomethylation in myeloma which is associated with poor prognosis. Topics discussed include methylation patterns which include global hypomethylation in asymptomatic myeloma and hypermethylation in symptomatic myeloma; role of transcription start site in regulation of gene expression; and relevance of gene promoter hypomethylation to survival outcomes in myeloma patients.