Back to Search
Start Over
Influence of metal complex formation on the antimicrobial activity of nifuroxazide: spectroscopic, electrochemical, and DFT studies.
- Source :
-
Journal of Coordination Chemistry . Jan2016, Vol. 69 Issue 2, p215-226. 12p. - Publication Year :
- 2016
-
Abstract
- [M(HL)2] complexes (M = Co(II) (1), Ni(II) (2), and Cu(II) (3); H2L = 4-hydroxybenzoic[(5-nitro-2-furanyl)methylene]hydrazide acid, nifuroxazide) were synthesized, characterized (by elemental analysis, TG, IR, UV–vis., EPR, magnetic, and conductance measurements) and tested for their antimicrobial activities. H2L is a mono-negative bidentate ligand via hydrazone N and C–O−forming intermediate complexes between tetrahedral and square-planar geometries (“flattened” tetrahedron,D2dsymmetry) for1and2, as well as square-planar for Cu(II) complex3. Natural bond orbital analysis revealed that the interaction of oxygen with metal ion is the main factor which determines the stability of1–3as the binding energy decreases with an increase in the M–O bond length. Time-dependent density functional theory calculations were carried out to understand the electronic transitions in related experimental observations. The reduction potential values of the nitro group are affected by the metal center. Ni(II) complex2displayed the highest activity among the tested complexes againstEscherichia coliwith a MIC50value of 0.098 μmol mL−1compared with 0.131 (1) and 0.117 μmol mL−1(3). [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00958972
- Volume :
- 69
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Coordination Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 112454911
- Full Text :
- https://doi.org/10.1080/00958972.2015.1111344