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A coupled 3D–1D numerical monodomain solver for cardiac electrical activation in the myocardium with detailed Purkinje network.
- Source :
-
Journal of Computational Physics . Mar2016, Vol. 308, p218-238. 21p. - Publication Year :
- 2016
-
Abstract
- We present a model for the electrophysiology in the heart to handle the electrical propagation through the Purkinje system and in the myocardium, with two-way coupling at the Purkinje–muscle junctions. In both the subproblems the monodomain model is considered, whereas at the junctions a resistor element is included that induces an orthodromic propagation delay from the Purkinje network towards the heart muscle. We prove a sufficient condition for convergence of a fixed-point iterative algorithm to the numerical solution of the coupled problem. Numerical comparison of activation patterns is made with two different combinations of models for the coupled Purkinje network/myocardium system, the eikonal/eikonal and the monodomain/monodomain models. Test cases are investigated for both physiological and pathological activation of a model left ventricle. Finally, we prove the reliability of the monodomain/monodomain coupling on a realistic scenario. Our results underlie the importance of using physiologically realistic Purkinje-trees with propagation solved using the monodomain model for simulating cardiac activation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219991
- Volume :
- 308
- Database :
- Academic Search Index
- Journal :
- Journal of Computational Physics
- Publication Type :
- Academic Journal
- Accession number :
- 112311352
- Full Text :
- https://doi.org/10.1016/j.jcp.2015.12.016