Back to Search
Start Over
Nanostructured lipid carriers as a potential vehicle for Carvedilol delivery: Application of factorial design approach.
- Source :
-
Artificial Cells, Nanomedicine & Biotechnology . Feb2016, Vol. 44 Issue 1, p12-19. 8p. - Publication Year :
- 2016
-
Abstract
- Present invention relates to design of nanostructured lipid carriers (NLC) to augment oral bioavailability of Carvedilol (CAR). In this attempt, formulations of CAR-NLCs were prepared with glyceryl-monostearate (GMS) as a lipid, poloxamer 188 as a surfactant and tween 80 as a co-surfactant using high pressure homogenizer by 23factorial design approach. Formed CAR-NLCs were assessed for various performance parameters. Accelerated stability studies demonstrated negligible change in particle size and entrapment efficiency, after storage at specified time up to 3 months. The promising findings in this investigation suggest the practicability of these systems for enhancement of bioavailability of drugs like CAR. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *LIPIDS
*GLYCERYL monostearate
*POLOXAMERS
*BIOAVAILABILITY
*SURFACE active agents
Subjects
Details
- Language :
- English
- ISSN :
- 21691401
- Volume :
- 44
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Artificial Cells, Nanomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 112233775
- Full Text :
- https://doi.org/10.3109/21691401.2014.909820