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Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo.
- Source :
-
Journal of Infectious Diseases . 2/1/2016, Vol. 213 Issue 3, p448-455. 8p. - Publication Year :
- 2016
-
Abstract
- Henipaviruses are zoonotic viruses that can cause severe and acute respiratory diseases and encephalitis in humans. To date, no vaccine or treatments are approved for human use. The presence of neutralizing antibodies is a strong correlate of protection against lethal disease in animals. However, since RNA viruses are prone to high mutation rates, the possibility that these viruses will escape neutralization remains a potential concern. In the present study, we generated neutralization-escape mutants, using 6 different monoclonal antibodies, and studied the effect of these neutralization-escape mutations on in vitro and in vivo fitness. These data provide a mechanism for overcoming neutralization escape by use of cocktails of cross-neutralizing monoclonal antibodies that recognize residues within the glycoprotein that are important for virus replication and virulence. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MONOCLONAL antibodies
*ZOONOSES
*RESPIRATORY diseases
*ENCEPHALITIS
*RNA viruses
*GLYCOPROTEINS
*GENETIC mutation
*ANIMAL experimentation
*GENETICS
*HAMSTERS
*IMMUNOGLOBULINS
*MICE
*PARAMYXOVIRUSES
*RESEARCH funding
*RODENTS
*VIRAL antibodies
*NEUTRALIZATION tests
*RNA virus infections
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 213
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 112206349
- Full Text :
- https://doi.org/10.1093/infdis/jiv449