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Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives.
- Source :
-
European Journal of Organic Chemistry . Jan2016, Vol. 2016 Issue 1, p41-44. 4p. - Publication Year :
- 2016
-
Abstract
- An efficient method to directly access the bicyclo[5.3.0]decane core was achieved by rhodium-catalyzed reaction of a novel donor-acceptor cyclopentenyl diazocarboxylate with a variety of furans. As this motif is commonly found within bioactive antitumor natural products, selected systems were further manipulated and evaluated against cancer cell lines sensitive to protein kinase C (PKC) activation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BICYCLODECENES
*RHODIUM
*CARBOXYLATES
*FURANS synthesis
*PROTEIN kinase C
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2016
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 112191456
- Full Text :
- https://doi.org/10.1002/ejoc.201501271