Back to Search
Start Over
Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jan2016, Vol. 26 Issue 2, p361-365. 5p. - Publication Year :
- 2016
-
Abstract
- Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C ( 3 ) and D ( 4 ), together with six known compounds ( 1 , 2 , and 5 – 8 ), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C ( 5 ) showed the strongest anti-HIV-1 activity with IC 50 of 1.4 ± 0.06 μM (selectivity index, 11.4), meanwhile aspernigrin C ( 3 ) also exhibited potent activity with IC 50 of 4.7 ± 0.4 μM (selectivity index, 7.5). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 26
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 112055769
- Full Text :
- https://doi.org/10.1016/j.bmcl.2015.12.005