BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology.

The article discusses a study related to supratentorial gliomas which reveals discrete genomic alterations to discriminate discriminate pilocytic astrocytomas, diffuse gliomas, and glioblastoma. Topics discussed includes co-deletion of chromosomes not revealed by loss of heterozygosity analysis for variant allele frequency, assess for the changes by transcriptional analysis of spinal cord astrocytomas, and success in BRAF-mutant cancer types with the BRAFâ€MEK inhibitors.