VALIDATION METHODS FOR WATER SYSTEMS OF PHARMACEUTICAL USE.

Water is a universal solvent. In pharmaceutical industry, water plays a vital role in the formulation and manufacturing of many products. Different types of waters are used for different types of dosage forms (e.g.: water for injection, sterile water for injection, purified water, etc.). If microbial purification and validation of water handling systems is not proper, this may have effect on quality. To produce best quality products, frequent monitoring, maintenance and validation of water handling systems and all the Total Organic Carbon content, inorganic, organic and microbial limits must be in specified limits as per USP specifications. The present article describes the need for validation and maintenance of water to produce good quality products. [ABSTRACT FROM AUTHOR]