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Connecting Tyrosine and Tryptophan Units of Diazonamide A and Azonazine by a Diastereodivergent Arylative Dearomatization.

Authors :
Denizot, Natacha
Guillot, Régis
Kouklovsky, Cyrille
Vincent, Guillaume
Source :
Chemistry - A European Journal. 12/21/2015, Vol. 21 Issue 52, p18953-18956. 4p.
Publication Year :
2015

Abstract

We report the Friedel-Crafts coupling of a tyrosine unit with tryptophan-derived pyrrolindolenium ions which are configurationally stable. The reaction allowed the stereoselective and divergent access to the required quaternary stereocenters found in diazonamide A and azonazine at the junction of the tyrosine and tryptophan units. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09476539
Volume :
21
Issue :
52
Database :
Academic Search Index
Journal :
Chemistry - A European Journal
Publication Type :
Academic Journal
Accession number :
111943142
Full Text :
https://doi.org/10.1002/chem.201503612