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A Convenient Synthesis of Spiro[isoxazole-pyrazoloquinoline] Derivatives under Catalyst-Free Conditions.
- Source :
-
Synthesis . 2016, Vol. 48 Issue 1, p65-72. 8p. - Publication Year :
- 2016
-
Abstract
- The same three-component reaction of aromatic aldehyde, 1H-indazol-6-amine and 3-phenylisoxazol-5(4H)-one in refluxing ethanol under catalyst-free conditions gave two entirely different kinds of products depending on the substituents on the benzene ring. The reaction selectively gave 5H-spiro[isoxazole-4,8'-pyrazolo[3,4-f]quinolin]-5-ones with strong electron-withdrawing groups on the aromatic aldehyde, while it resulted in ring-opened pyrazoloquinoline derivatives with other substituents. The former structure was confirmed by X-ray diffraction analysis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 48
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 111918806
- Full Text :
- https://doi.org/10.1055/s-0035-1560492