A Novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C 21 H 26 N 2 O 8 ): Microwave-Irradiated Hantzsch Ester Synthesis, Characterization and Molecular Crystal.

The novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine was synthesized through multicomponent one pot Hantzsch ester synthesis using 4,5-dimethoxy-2-nitrobenzaldehyde, ethyl 3-oxobutanoate, and ammonium carbonate under microwave irradiation and subsequently characterized by several spectroscopic techniques, i.e., ESI mass, IR,1H, and13C NMR along with single crystal X-ray diffraction method. The single crystal of 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8) was developed in 0.35 × 0.30 × 0.25 mm dimension in methanol. The crystal structure parades only intermolecular hydrogen bonding of the N(2)-H(2A) … O(2) type and the boat conformation of the dihydropyridine ring. [ABSTRACT FROM PUBLISHER]