Back to Search
Start Over
24-hour pH-impedance monitoring on therapy to select patients with refractory reflux symptoms for antireflux surgery. A single center retrospective study.
- Source :
-
Neurogastroenterology & Motility . Jan2016, Vol. 28 Issue 1, p146-152. 7p. - Publication Year :
- 2016
-
Abstract
- Background Treatment of gastro-esophageal reflux refractory symptoms is challenging. This monocenter retrospective study assessed the value of preoperative pH-impedance monitoring 'on' therapy to predict functional outcome after laparoscopic fundoplication in patients with refractory reflux symptoms. Methods Patients with a preoperative pH-impedance monitoring 'on' proton pump inhibitors ( PPIs) twice daily were assessed at least 6 months after a laparoscopic fundoplication for refractory reflux symptoms. Failure of fundoplication was defined by a Visick score > 2. Postoperative symptoms were assessed by the reflux disease questionnaire ( RDQ). The pH-impedance parameters analyzed were the number of reflux events (total, acid, non-acid), esophageal acid exposure time, esophageal bolus exposure time, and symptom-reflux association defined by symptom index ( SI) >50% and symptom association probability ( SAP) >95%. Key Results Thirty-three patients (18 female patients, median age 46 years) were assessed after a mean follow-up of 41.3 (range 7-102.2) months. Seven (21.2%) patients were considered as failures. Compared to patients with favorable outcome, these patients were more often 'on' PPI therapy (86% vs 23%, p < 0.05) and had higher RDQ scores in each domain: heartburn ( p < 0.05), regurgitation ( p < 0.05) and dyspepsia ( p < 0.05). A positive SAP was the only pH-impedance parameter statistically associated with successful postoperative outcome ( p = 0.004). Conclusions & Inferences On therapy, a preoperative positive symptom association probability is the only pH-impedance parameter associated with favorable outcome after laparoscopic fundoplication for refractory reflux symptoms. These results should be confirmed by prospective studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13501925
- Volume :
- 28
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neurogastroenterology & Motility
- Publication Type :
- Academic Journal
- Accession number :
- 111888879
- Full Text :
- https://doi.org/10.1111/nmo.12715