Back to Search
Start Over
Biomineralization-inspired synthesis of chitosan/hydroxyapatite biocomposites based on a novel bilayer rate-controlling model.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Dec2015, Vol. 136, p457-464. 8p. - Publication Year :
- 2015
-
Abstract
- In order to prepare sophisticated biomaterials using a biomimetic approach, a deeper understanding of biomineralization is needed. Of particular importance is the control and regulation of the mineralization process. In this study, a novel bilayer rate-controlling model was designed to investigate the factors potentially influencing mineralization. In the absence of a rate-controlling layer, nano-scale hydroxyapatite (HA) crystallites exhibited a spherical morphology, whereas, in the presence of a rate-controlling layer, HA crystallites were homogeneously dispersed and spindle-like in structure. The mineralization rate had a significant effect on controlling the morphology of crystals. Furthermore, in vitro tests demonstrated that the reaction layer containing spindle-like HA crystallites possessed superior biological properties. These results suggest that a slow mineralization rate is required for controlling the morphology of inorganic crystallites, and consumption by the rate-controlling layer ensured that the ammonia concentration remained low. This study demonstrates that a biomimetic approach can be used to prepare novel biomaterials containing HA crystallites that have different morphologies and biological properties. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOMINERALIZATION
*CHITOSAN
*BIOMATERIALS
*HYDROXYAPATITE
*BIOMIMETIC materials
Subjects
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 136
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 111877095
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2015.09.027