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IFN-γ 874A>T Genotype Is Associated With Higher CCR5 Expression in Peripheral Blood Mononuclear Cells From HIV+ Patients.
- Source :
-
JAIDS: Journal of Acquired Immune Deficiency Syndromes . 12/15/2011, Vol. 58 Issue 5, p442-445. 4p. - Publication Year :
- 2011
-
Abstract
- We previously showed that certain cytokines impact on the expression of drug transporters and chemokine receptors in peripheral blood mononuclear cells. Known single-nucleotide polymorphism genes in the genes encoding interferon γ (874A>T, rs62559044) and interleukin 2 (-330T>G, rs2069763) were genotyped in 66 HIV+ patients, and the impact of single-nucleotide polymorphisms on expression of ABCB1, ABCC1, ABCC2, CXCR4, and CCR5 in peripheral blood mononuclear cells from HIV+ patients was assessed. The IFN-γ 874A>T allele and viral load were independently associated with CCR5 expression in patients. These associations have potential implications for HIV disease progression and treatment response that now warrant further study. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15254135
- Volume :
- 58
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- JAIDS: Journal of Acquired Immune Deficiency Syndromes
- Publication Type :
- Academic Journal
- Accession number :
- 111807063
- Full Text :
- https://doi.org/10.1097/QAI.0b013e318236441c