Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants

Authors :: Perni, Robert B.
Britt, Shawn D.
Court, John C.
Courtney, Lawrence F.
Deininger, David D.
Farmer, Luc J.
Gates, Cynthia A.
Harbeson, Scott L.
Kim, Joseph L.
Landro, James A.
Levin, Rhonda B.
Luong, Yu-Ping
O'Malley, Ethan T.
Pitlik, Janos
Rao, B. Govinda
Schairer, Wayne C.
Thomson, John A.
Tung, Roger D.
Van Drie, John H.
Wei, Yunyi
Source :: Bioorganic & Medicinal Chemistry Letters. Nov2003, Vol. 13 Issue 22, p4059. 5p.
Publication Year :: 2003
Abstract: Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed. [Copyright &y& Elsevier]

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