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2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2003, Vol. 13 Issue 22, p3997. 4p. - Publication Year :
- 2003
-
Abstract
- 2-Arylamino-4-trifluoromethyl-5-aminomethylthiazoles represent a novel series of high-affinity corticotropin releasing factor-1 receptor (CRF1R) antagonists that are prepared in three steps in good overall yields. Herein, we report binding SAR as well as anxiolytic activity of an exemplary compound (7a, Ki=8.6 nM) in a mouse canopy model. [Copyright &y& Elsevier]
- Subjects :
- *THIAZOLES
*CORTICOTROPIN releasing hormone
*AMINO compounds
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 13
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 11173380
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.08.055