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Evaluation of a Pharmacy-Managed Pharmacokinetic Dosing Program.

Evaluation of a Pharmacy-Managed Pharmacokinetic Dosing Program.

Authors :
Meyenburg, Lyndsi K.
Crannage, Andrew J.
Murphy, Julie A.
Korobey, Matthew J.
Source :
Journal of Pharmacy Practice. Dec2015, Vol. 28 Issue 6, p529-534. 6p.
Publication Year :
2015

Abstract

Purpose: The objective of this study was to determine the impact of a pharmacy-managed pharmacokinetic dosing program on appropriate dosing of famotidine, enoxaparin, and ketorolac. Methods: A large community teaching hospital implemented a pharmacy-managed pharmacokinetic dosing program for famotidine, enoxaparin, and ketorolac. Subjects were included if they received famotidine and had a creatinine clearance (CrCl) of <50 mL/min; received therapeutic enoxaparin and had a CrCl of <30 mL/min; or received ketorolac and had a CrCl <30 mL/min, age <underline>></underline> 65 years or weight <50 kg. Results: One hundred and forty-six patients were included in the preimplementation group (famotidine [n = 50], enoxaparin [n = 46], and ketorolac [n = 50]) and 143 patients were included in the postimplementation group (famotidine [n = 50], enoxaparin [n = 43], and ketorolac [n = 50]). In all, 66% of patients were dosed appropriately in the preimplementation group (famotidine 28%, enoxaparin 85%, and ketorolac 86%) compared to 94% in the postimplementation group (famotidine 92%, enoxaparin 95%, and ketorolac 94%), P < .001. Conclusion: Implementation of a pharmacy-managed pharmacokinetic dosing program significantly improved appropriate dosing of famotidine, enoxaparin, and ketorolac. These findings could justify expansion of pharmacist autonomy through institution–approved, pharmacy-managed programs for other medications to improve appropriate dosing. Analyses specifically evaluating patient-oriented or financial outcomes may provide additional support for expansion. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08971900
Volume :
28
Issue :
6
Database :
Academic Search Index
Journal :
Journal of Pharmacy Practice
Publication Type :
Academic Journal
Accession number :
111546306
Full Text :
https://doi.org/10.1177/0897190014544825