Apolipoprotein E Binding to Low Density Lipoprotein Receptor-related Protein-1 Inhibits Cell Migration via Activation of cAMP-dependent Protein Kinase A.

Tests the hypothesis that apolipoprotein E (apoE) inhibition of cell migration is mediated through the activation of cAMP/protein kinase A pathways. Results showing that apoE increased intracellular cAMP levels after five minutes and that the increase was sustained for more than an hour; Failure of apoE to increase cAMP levels or inhibit migration of LRP-1-negative mouse embryonic fibroblasts and LRP-1-deficient smooth muscle cells.