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DNA damage response in cisplatin-induced nephrotoxicity.

DNA damage response in cisplatin-induced nephrotoxicity.

Authors :
Zhu, Shiyao
Pabla, Navjotsingh
Tang, Chengyuan
He, Liyu
Dong, Zheng
Source :
Archives of Toxicology. Dec2015, Vol. 89 Issue 12, p2197-2205. 9p. 4 Diagrams.
Publication Year :
2015

Abstract

Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03405761
Volume :
89
Issue :
12
Database :
Academic Search Index
Journal :
Archives of Toxicology
Publication Type :
Academic Journal
Accession number :
111455707
Full Text :
https://doi.org/10.1007/s00204-015-1633-3